Although the aforementioned studies suggest that PEMF effects on the Ca/CaM/NO cascades were responsible for the reported biologic effects, cellular and animal studies in which the use of inhibitors for selected steps in this cascade provide the strongest support. One well-designed study clearly showed DNA synthesis in articular chondrocytes in vitro was increased by PEMF via a NO pathway. This study systematically used CaM, NOS, and cGMP inhibitors that individually eliminated the PEMF effect on DNA synthesis.55 PEMF effects on osteoblast proliferation and differentiation were shown to be mediated by NO.56 Direct evidence of the effect of a PEMF signal configured for the Ca/CaM pathway on real-time NO production in a neuronal cell line, which could be eliminated by CaM and NOS inhibitors, has also recently been reported.57,58 Finally, 2 of the authors (BS and AAP) showed that PEMFs configured for the NO pathway significantly increased angiogenesis in a thermal myocardial injury in the rat.59,60 This effect was eliminated in rats who were fed NG-nitro-L-arginine methyl ester (L-NAME), a NOS inhibitor (Figure 3).
Recently I published the first new feature article for PainScience.com in quite a while: Zapped! Does TENS work for pain? The peculiar popularity of being gently zapped with electrical stimulation therapy. I’ve now added an interesting new section to it about pulsed electromagnetic field therapy (PEMF). It’s amazingly positive, and inspired by some fresh science …
Bone regeneration can be accelerated in osteotomies made 3.5–4.5 cm distal to the head of the fibula in dogs. A voltage field was induced in the fibula by inductively coupling pulsed electromagnetic fields of low frequency and strength directly to the bone across the skin. Not only did the stimulated osteotomies heal faster than control osteotomies but the regenerated bone was also more highly organized and stronger than control regenerated bone, even though the mass of callus formed was less than in controls. This method has been used to successfully treat tibial pseudoarthroses in young patients. Pseudoarthrosis is a rare, local bone dysplasia that has a very low probability of correction by conventional techniques. Pulsed electromagnetic fields have also been used as a noninvasive postoperative treatment for lumbar vertebral fusion.
A reference source for information related to PEMF devices and PEMF therapy in general. Learn about the effects of PEMF Devices and ways to utilize them directly from the experts in the field of PEMF. Curated original articles written by experts such as Dr. Pawluk and affiliated PEMF brands. Easy access to the thought leaders and indepth technical knowledge about Pulsed Electromagnetic Fields for therapeutic uses.
Pulsed signal therapy is the result of three decades of research designed to characterise the piezoelectric signal that normally stimulates chondrocyte activity by creating a streaming potential in the extracellular matrix when bone is subjected to pressure. Although the transmission of this signal is impaired in OA, PST can reproduce this streaming potential in affected joints under no load, and the nine one-hour daily non-invasive treatments are devoid of any adverse side effects. Long term follow up confirms sustained pain relief, improved mobility, and a high safety profile as assessed by validated instruments (WOMAC, OMERAC, modified Ritchie scales) as well as evaluations by doctors and patients.
The basic science work accomplished to date provides strong support for the proposal that modulation of Ca2+ binding to CaM, upon a transient increase in intracellular calcium when homeostasis is interrupted,48 is an important PEMF transduction pathway. It is likely that the disruption of the tightly regulated Ca2+ balance in cells is the natural signal to provoke the endogenous tissue repair and regeneration mechanism, hence the apparent simple acceleration of normal healing activity by targeted PEMF signals. Ca/CaM catalyzes eNOS, which allows the PEMF signal to modulate the release of NO from eNOS and potentially affect the entire tissue repair pathway, from pain and edema to angiogenesis, bone and tissue regeneration, and other regenerative actions. PEMF signals configured to target the Ca/CaM pathway have been applied to rat tendon and wound healing.49,50 In both studies, tendon and wound healing rates were seen to significantly increase by 59% ± 4% (Figure 1, A) and 69% ± 5% (Figure 1, B) in PEMF-treated animals.
The presence and size of a full-thickness rotator cuff tear may limit potential for management with exercise and underscores the importance of correct diagnosis. However, at least in a subset of patients with impingement non-operative management is equally effective as open or arthroscopic decompression (Coghlan et al 2008). Haahr et al (2005) noted no between-group differences at 12 months for pain and function in patients treated with subacromial arthroscopic decompression or 19 sessions of rotator cuff and scapular strengthening augmented by thermotherapy and massage. Faber et al (2006) reported no significant difference between supervised exercise therapy and arthroscopic acromioplasty with regard to return to work status at 6 months and at 2.5 years.
PEMF therapy is more commonly used in Europe to treat many ailments, including cancer. Although only two clinical studies have used PEMF therapy for cancer treatment, these studies show that PEMF therapy is safe and promising compared to other available cancer therapies. PEMFs could be used not only as primary therapy but also in combination with other common antineoplastic therapies. Given that new portable and affordable PEMF devices are increasingly available on the market, future controlled clinical studies are expected to further determine the potential of PEMF therapy in conventional oncology.
Je fais maths tous les après-midi. Les trois niveaux en même temps. Cela me permet de faire fonctionner à plein l'entraide et de faire travailler les élèves au niveau qui leur correspond. Ainsi, j'ai actuellement un élève de CE1 qui cartonne en math (il a directement attaqué le fichier CE2 cette année et est en tête du groupe). L'an passé, j'avais à l'inverse un élève très en difficulté qui travaillait sur le fichier CE1 alors qu'il était au CE2. Alors oui, cet élève n'a pas suivi le programme de CE2 MAIS il a progressé, sans installer de nouvelles lacunes. Et le fait de se voir progresser (changer de série) a renforcé son estime de lui.